Description

5-Amino-1-methylquinolinium chloride is an enzyme overexpressed during skeletal muscle aging and is associated with repair of NAD+ pathway damage, dysregulated sirtuin1 activity, and increased muscle stem cell senescence. 5-Amino-1-methylquinolinium chloride promotes myoblast differentiation in vitro and enhances fusion and regeneration of muscle stem cells in aged mice. 5-Amino-1-methylquinolinium chloride is also a potent inhibitor of nicotinamide N-methyltransferase (NNMT), selectively binding to NNMT substrate binding site residues. 5-Amino-1-methylquinolinium chloride promotes myoblast differentiation in vitro and enhances fusion and regeneration of muscle stem cells in aged mice. Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism.

5-Amino-1-Methylquinolinium Chloride works within your microbiome to reduce adipose (fat) tissue and help you lose weight.When extra fat cells accumulate, your body overproduces an enzyme known as NNMT (nicotinamide N-methyltransferase). The more NNMT, the more your body increases inflammation and stores fat. 5-Amino-1-Methylquinolinium Chloride inhibits NNMT, allowing your body to drop excess weight.